Cochlear inner ear hair cells

The mammalian cochlea

Cochlear inner ear hair cells

Outer hair cells with or without Nesprin4

Genomics of deafness

tipa biobank

We were awarded the Israel Precision Medicine Partnership (IPMP) grant with the Maccabi Tipa Biobank 

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Our new paper "Consensus interpretation of the p.Met34Thr and p.Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel" is out! 

Main research interests of our lab

A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.

The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.

At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. 

biochemistry

Genes that lead to hearing loss

What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?

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Regulation of gene expression

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Publications

DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium

Genetics of hearing loss in the Arab population of Northern Israel

Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness.

miR-96 is required for normal development of the auditory hindbrain

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Single cell analysis of the inner ear sensory organs

News

Congratulations to Karen Avraham for the Beutler Research Program of Excellence in Genomic Medicine Award

Our whole genome methylome of the inner ear is published!

Yizhar-Barnea, Valensisi et al paper “DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium” is out https://rdcu.be/bbZlz

Danial-Farran et al paper in EJHG is out!

Genetics of hearing loss in the Arab population of Northern Israel was published at the European Journal of Human Genetics. https://rdcu.be/43DN

Congratulations to Shahar !

Shahar Taiber has been invited to attend the XIN Innovation Forum event in Beijing in October 2018!

Congrats to Mor Bordeynik-Cohen for getting her MSc!

HL-EP ACMG/AMP variant specification paper on bioRxiv

Interested in exploring

Contact us

Karen pic

PROF. KAREN B. AVRAHAM Principal Investigator Vice Dean, Sackler Faculty of Medicine

Email: karena@tauex.tau.ac.il
Telephone: +972-3-6406642
Fax: +972-3-6409360
Ms. Helen Berman

HELEN BERMAN Administrative Assistant

Email: Helenbe@tauex.tau.ac.il
Telephone: +972-3-6406642
Fax: +972-3-6409360

Address

Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine

10th floor, room 1003
Tel Aviv University
Tel Aviv 6997801 Israel

Research funding

grants
inner-earAsset 2@2x

Future conferences

 

2nd International Symposium on Inner Ear Therapeutics

Nov 4-6, 2019, Hannover, Germany

 

The 16th Transgenic Technology Meeting - TT 2020

25-28.10.2020, Science of Institute Weizmann, Israel