Dr. Avraham is Full Professor at the Department of Human Molecular Genetics and Biochemistry and Vice Dean at the Sackler Faculty of Medicine, Tel Aviv University. Born in Canada and raised in the US, Dr. Avraham received her B.A. degree from Washington University in St. Louis, Missouri and then went on to perform her Ph.D. at the Weizmann Institute of Science in Rehovot, Israel. Her doctoral thesis focused on the development of a model for Down syndrome. She performed her postdoctoral training at the National Cancer Institute in Frederick, Maryland, USA in mammalian genetics. Read more…
Zippi received her Bachelor’s degree in Communication Disorders at Tel Aviv University and her Master’s degree in Genetics at the Hebrew University of Jerusalem. Her graduate studies, as well as her post-doctoral training were completed in genetics, in our laboratory, where she worked on identifying and characterizing genes involved in deafness in the Jewish population. Today, Zippi continues her work in our lab as a Research Associate, combining experimental and computational techniques in order to detect all the ‘deafness genes’ in the Jewish population and reach a comprehensive view of the roles these genes play in hearing and deafness.
Amiel received his B.Sc. degree at the Faculty of Agriculture, Food and Environment of the Hebrew University, Rehovot, Israel. In parallel to his bachelor’s studies, he worked as a laboratory assistant in the Department of Plant Sciences at the Weizmann Institute of Science, where he was exposed to the world of transposable elements and homologous recombination. He then decided to pursue his studies in the field of genetics. His Ph.D., obtained in 2012, focused on studying the mechanisms that underlie deafness as a result of SLC26A4 mutations. Human mutations in SLC26A4 lead to a non-syndromic (DFNB4) and syndromic form of deafness with enlargement of the thyroid gland (Pendred syndrome). In particular, he studied an ENU-generated mouse model, loop, with a mutation in the Slc26a4 gene. He continues to perform research in the lab on thyroid dysfunction in the loop mice, in between classes in the Sackler Four Year medical school program.
Kathy received her Bachelor Honors Degree in Pharmacology from University College London (UCL), United Kingdom. While at UCL she joined the laboratory of Dr. Jonathan Gale at The UCL Ear Institute, where she worked on the role of mitochondrial permeability transition pore (MPTP) in neomycin-induced hair cell death. She completed her Master’s Degree in Biology at the University of Geneva, Switzerland. She carried out her research in the laboratory of Prof. Luca Scorrano to work on mitochondrial dynamics and apoptosis. During this period she set up a system for a novel super-resolution microscopy approach to reveal the role of mitochondrial subcompartments during pathophysiological conditions.
Ofer received his B.Sc in Life Sciences from Ben-Gurion University at the Negev. For 6 years he was part of and managed a non-conventional defensive measures R&D team in the Ministry of Defense (ISR), during which time he gained knowledge in physical modeling of complex chemical/biological and meteorological phenomenon. He graduated with honors in his M.Sc studies in the Biotech & Food Engineering Faculty at the Technion, during which time he worked on the regulation of lineage-specific expression of IRF-8 in myeloid cells in the laboratory of Prof. Ben-Zion Levi. During this period he gained experience in epigenetics and a wide verity of molecular biology research methodologies, together with knowledge in general and biotech-specific engineering.
Kobi Perl, M.D., Ph.D student Kobi received his B.Sc. in Chemistry and Life Sciences, cumma sum laude, from the Open University of Israel. He is currently studying toward his M.D.-Ph.D. in the Four Year M.D. Program at Tel Aviv University, together with research in the Department of Human Molecular Genetics and Biochemistry. His project focuses on the understanding of developmental and physiological conditions of the inner ear using transcriptome and proteome analysis. His research is in cooperation with Prof. Ron Shamir from the School of Computer Science.
Nada received her B.Sc. in medical laboratory studies from the Technion in Haifa. Her M.Sc. was completed in the Institute of Evolution at the University of Haifa. During her M.Sc. degree studies she joined the Institute of Genetics at Ha’emek Medical Center in the Molecular Genetics lab and one year later she became active in the Genetics Clinic as a genetic counselor. Currently she is a Ph.D. student in Karen Avraham’s laboratory, with joint advisor Prof. Stavit Shalev. Her challenge is to bridge between basic science research and medicine by addressing novel genes and mutations involved in hearing loss among families from Northern Israel, including different ethnic groups, by using Next-generation sequencing.
Tal received her B.Sc. in Life Sciences from Tel Aviv University. She completed her M.Sc. in Molecular Biology at the Faculty of Natural Sciences at Ben-Gurion University of the Negev, Beer-Sheva. After finishing her Master’s degree, she began working at the Molecular-Genetic laboratory at the Wolfson Medical Center, collaborating with the Genetics Institute and the Metabolic, Genetic, Neurologic Children’s Clinic. During her work she performed genetic and bioinformatic analysis with the aim of finding the genetic basis of different diseases and syndromes. Her current project focuses on the role of competing endogenous RNA (ceRNA) networks in regulating the mechanisms of hearing and deafness.
Christina received her B.Sc. degree at the Faculty of Life Sciences at Tel Aviv University, after which time she joined the Institute of Genetics at Rambam Health Care Campus in Haifa. She is currently an M.Sc. student in our laboratory. Her project involves defining the molecular and genetic basis of hearing impairment using high-throughput sequencing, along with advisor Dr. Hagit Baris.
Yael received her B.Sc. in Biotechnology from Bar-Ilan University. During her undergraduate studies she took part in a project in Dr. Shay Ben-Aroya’s laboratory in order to characterize the role of deubiquitinating enzyme during the DNA damage response. She is currently an M.Sc student in our laboratory working on discovery of new variants associated with deafness and understanding their molecular mechanism.
The team in Karen Avraham's laboratory at Tel Aviv University works to understand the molecular basis of deafness. We carry out genomic evaluation of inherited hearing loss and study genetic regulation of the function of the inner ear. We use advanced genomic technologies, including hybridization capture and deep sequencing, and model organisms to accomplish these goals.