Cochlear inner ear hair cells

The mammalian cochlea

Cochlear inner ear hair cells

Outer hair cells with or without Nesprin4

Main research interests of our lab

A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.

The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.

At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. 

biochemistry

Genes that lead to hearing loss

What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?

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Regulation of gene expression

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Publications

Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness.

miR-96 is required for normal development of the auditory hindbrain

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Single cell analysis of the inner ear sensory organs

Reduced changes in protein compared to mRNA levels across non-proliferating tissues

Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.

Doetzlhofer A, Avraham KB.

News

Congratulations to Shahar !

Shahar Taiber has been invited to attend the XIN Innovation Forum event in Beijing in October 2018!

HL-EP ACMG/AMP variant specification paper on bioRxiv

Congratulations to Mor for winning The Herczeg Institute on Aging scholarship award

NIH NIDCD grant has begun!

Perl et al manuscript has been accepted to Human Genomics

Our manuscript by Perl et al “Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness” has been accepted to Human Genomics!

Prof. Mary Claire King talks about winning the Dan David prize and her work with our lab

Interested in exploring

Contact us

Karen-Contact

PROF. KAREN B. AVRAHAMPrincipal Investigator Vice Dean, Sackler Faculty of Medicine

Email:karena@tauex.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360
Ms. Helen Berman

HELEN BERMANAdministrative Assistant

Email:Helenbe@tauex.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360

Address

Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine

10th floor, room 1003
Tel Aviv University
Tel Aviv 6997801 Israel

Research funding

grants
inner-earAsset 2@2x

Future conferences

 

The 7th Graduate Student Conference on Genetics,Genomics and Evolution
Sep 4th, 2018, Jerusalem, Israel
https://www.facebook.com/events/619365565122694/?active_tab=about
Molecules in Biology and Medicine
Sept 11-14, 2018, Basel, Switzerland
Modeling Hearing & Balance Disorders in Mice: the HEar@JAX Workshop,
Sept 23-28, Jackson Laboratory, Bar Harbor, Maine, USA
http://2018www.jax.org/ear
JAX workshop 2018 flyer
10th International Symposium on Objective Measures in Auditory Implants (OMAI),
Oct 9-12, 2018
, Tel Aviv, Israel
http://objectivemeasures.org/
Association for Research in Otolaryngology (ARO)
42nd Annual MidWinter Meeting
Feb 9-13, 2019, Baltimore, MD, USA
Human Genome Meeting (HGM) 2019 - Towards Implementing Genomic Medicine
April 24-27, 2019, Seoul, South Korea