Cochlear inner ear hair cells

The mammalian cochlea

Genomics of deafness

Yael-Noy

Congratulations to Yael Noy!

On becoming a direct Phd student

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Scientific Reports

lncRNA paper published

Genome-wide identification and expression profiling of long non- coding RNAs in auditory and vestibular systems

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Main research interests of our lab

A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.

The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.

At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. 

biochemistry

Genes that lead to hearing loss

What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?

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Regulation of gene expression

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Publications

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Single cell analysis of the inner ear sensory organs

Reduced changes in protein compared to mRNA levels across non-proliferating tissues

Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.

Doetzlhofer A, Avraham KB.

What’s hot about otoferlin.

Avraham KB.

The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI.

Marcotti W, Corns LF, Goodyear RJ, Rzadzinska AK, Avraham KB, Steel KP, Richardson GP, Kros CJ.

Our group

Current Members

Prof. Karen B. Avraham

Prof. Karen B. Avraham

Zippora (Zippi) Brownstein, Ph.D.

Dr. Zippora (Zippi) Brownstein

amal

Amal Abu Raayan

Ofer

Ofer Barnea-Yizhar

Mor BC

Mor Bordeynik-Cohen

Nada Danial-Faran photo

Nada Danial-Farran

Amiel Dror, M.D.-Ph.D. student

Dr. Amiel Dror

Tal-Koffler-photo

Tal Koffler

Prata

Prathamesh Thangaraj Nadar Ponniah

Yael-Noy

Yael Noy

IMG_20171008_085238_01

Shahar Taiber

News

Our lncRNA paper in the news

Congratulations to Mor for passing to the next stage of her MD-PhD

Congratulations to Mor for passing to the next stage of her MD-PhD

Shahar Taiber – accepted as an MD-PhD student

Congratulations!

Amal Abu-Rayyan, ASHG Travel Fellowship

Congratulations to Amal Abu-Rayyan being awarded an ASHG Travel Fellowship!

lncRNA paper published in Scientific Reports

congratulations kathy on publishing: Genome-wide identification and expression profiling of long non- coding RNAs in auditory and vestibular systems

“What’s hot about otoferlin” now on line in the EMBO Journal

Interested in exploring

Contact us

Karen-Contact

PROF. KAREN B. AVRAHAMPrincipal Investigator Vice Dean, Sackler Faculty of Medicine

Email:karena@tauex.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360
Ms. Helen Berman

HELEN BERMANAdministrative Assistant

Email:helenbe@post.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360

Address

Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine
Tel Aviv University
Tel Aviv 6997801 Israel

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Are you interested in the research of hearing impairment and human genetics?