Cochlear inner ear hair cells

The mammalian cochlea

Cochlear inner ear hair cells

Outer hair cells with or without Nesprin4

Genomics of deafness

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Dr Kathy Ushakov was awarded her PhD!

Our research: "DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory organ of Corti has been deposited at bioRxiv.

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Congratulations to Ofer

Ofer Yizhar-Barnea has won the  GSI 2018 Poster Award!

Main research interests of our lab

A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.

The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.

At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. 

biochemistry

Genes that lead to hearing loss

What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?

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Regulation of gene expression

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Publications

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Single cell analysis of the inner ear sensory organs

Reduced changes in protein compared to mRNA levels across non-proliferating tissues

Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.

Doetzlhofer A, Avraham KB.

What’s hot about otoferlin.

Avraham KB.

The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI.

Marcotti W, Corns LF, Goodyear RJ, Rzadzinska AK, Avraham KB, Steel KP, Richardson GP, Kros CJ.

Our Group

Current Members

Prof. Karen B. Avraham

Prof. Karen B. Avraham

Zippora (Zippi) Brownstein, Ph.D.

Dr. Zippora (Zippi) Brownstein

amal

Amal Abu Raayan

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Duaa Ali-Naffaa

Ofer

Ofer Barnea-Yizhar

Mor BC

Mor Bordeynik-Cohen

amal D lab

Amal Damoni

Nada Danial-Faran photo

Nada Danial-Farran

Amiel Dror, M.D.-Ph.D. student

Dr. Amiel Dror

Tal-Koffler-photo

Tal Koffler

Prata

Prathamesh Thangaraj Nadar Ponniah

Yael-Noy

Yael Noy

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Dr. Nofrat Schwartz

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Shahar Taiber

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Dr. Ruth Yusovich

News

Congratulations to Ofer and Shahar for their winnings!

Congratulations to Shahar on being awarded the Action on Hearing Loss – Flexi Grant 2018 and to Ofer Yizhar-Barnea on winning the GSI 2018 Poster Award!

lncRNA paper published in Scientific Reports

congratulations kathy on publishing: Genome-wide identification and expression profiling of long non- coding RNAs in auditory and vestibular systems

Amal Abu-Rayyan, ASHG Travel Fellowship

Congratulations to Amal Abu-Rayyan being awarded an ASHG Travel Fellowship!

Shahar Taiber – accepted as an MD-PhD student

Congratulations!

Congratulations to Mor for passing to the next stage of her MD-PhD

Congratulations to Mor for passing to the next stage of her MD-PhD

Our lncRNA paper in the news

Interested in exploring

Contact us

Karen-Contact

PROF. KAREN B. AVRAHAMPrincipal Investigator Vice Dean, Sackler Faculty of Medicine

Email:karena@tauex.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360
Ms. Helen Berman

HELEN BERMANAdministrative Assistant

Email:helenbe@post.tau.ac.il
Telephone:+972-3-6406642
Fax: +972-3-6409360

Address

Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine
Tel Aviv University
Tel Aviv 6997801 Israel

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Future conferences

 

Mediterranean Society of Otology & Audiology (MSOA) 16th International Meeting,
May 13-16, 2018, Jerusalem, Israel
http://msoa2018.org/
 

 

 

Molecular Biology of Hearing & Deafness,
May 16-19, 2018, Gottingen, Germany

 

 

Modeling Hearing & Balance Disorders in Mice: the HEar@JAX Workshop,
Sept 23-28, Jackson Laboratory, Bar Harbor, Maine, USA
http://2018www.jax.org/ear
JAX workshop 2018 flyer

 

 

10th International Symposium on Objective Measures in Auditory Implants (OMAI),
Oct 9-12, 2018
, Tel Aviv, Israel

http://objectivemeasures.org/