Main research interests of our lab
A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.
The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.
At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail.
Genes that lead to hearing loss
What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?
Regulation of gene expression
How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?
Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems
Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.
Doetzlhofer A, Avraham KB.
Congratulations to Shahar !
Shahar Taiber has been invited to attend the XIN Innovation Forum event in Beijing in October 2018!
Perl et al manuscript has been accepted to Human Genomics
Our manuscript by Perl et al “Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness” has been accepted to Human Genomics!
A fascinating journey
We use state-of-the-art imaging tools, including advanced confocal and elctron microscopy, to study the pathophysiology of hearing impairment as a result of genetic mutations.
PROF. KAREN B. AVRAHAMPrincipal Investigator Vice Dean, Sackler Faculty of Medicine
HELEN BERMANAdministrative Assistant
Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine
10th floor, room 1003
Tel Aviv University
Tel Aviv 6997801 Israel
Modeling Hearing & Balance Disorders in Mice: the HEar@JAX Workshop,
Sept 23-28, Jackson Laboratory, Bar Harbor, Maine, USA
JAX workshop 2018 flyer
10th International Symposium on Objective Measures in Auditory Implants (OMAI),
Oct 9-12, 2018, Tel Aviv, Israel
The 7th Graduate Student Conference on Genetics,Genomics and Evolution
Sep 4th, 2018, Jerusalem, Israel