Main research interests of our lab
A major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing.
The auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime.
At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail.
Genes that lead to hearing loss
What are the genes that lead to hearing loss and how are they involved in normal function of the inner ear?
Regulation of gene expression
How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?
DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium
Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness.
Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems
Congratulations to Karen Avraham for the Beutler Research Program of Excellence in Genomic Medicine Award
Our whole genome methylome of the inner ear is published!
Yizhar-Barnea, Valensisi et al paper “DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium” is out https://rdcu.be/bbZlz
Danial-Farran et al paper in EJHG is out!
Genetics of hearing loss in the Arab population of Northern Israel was published at the European Journal of Human Genetics. https://rdcu.be/43DN
Congratulations to Shahar !
Shahar Taiber has been invited to attend the XIN Innovation Forum event in Beijing in October 2018!
PROF. KAREN B. AVRAHAMPrincipal Investigator Vice Dean, Sackler Faculty of Medicine
HELEN BERMANAdministrative Assistant
Dept. of Human Molecular
Genetics & Biochemistry
Sackler Faculty of Medicine
10th floor, room 1003
Tel Aviv University
Tel Aviv 6997801 Israel
Mammalian Sensory Systems (C4)